Harris Lab News Archive

2017      (Click to expand/collapse year)

July
Congratulations to PhD student Brett Anderson who just successfully defended his thesis titled, "APOBEC3 Transcriptional Regulation and HIV-1 Restriction in T Lymphocytes."

Congratulations to PhD student Gabriel Starrett who just successfully defended his thesis titled, "Converging functions of APOBEC enzymes in viral infections and cancer."

May
Lab members Jiayi Wang, Dr. Diako Ebrahimi, and Dr. Terumasa Ikeda attended the Cold Spring Harbor Laboratory Meeting on Retroviruses. Diako gave a talk on APOBEC3H variation in humans and Jiayi gave a talk on the SIV Vif-human APOBEC3B interaction, while Teru presented a poster on opossum APOBEC1.

Lab members Amy Molan and Dr. Diako Ebrahimi gave oral presentations at the local Institute for Molecular Virology Annual Symposium and other lab members, Christopher Richards, Gabriel Starret, Jiayi Wang, Dr. Terumasa Ikeda, and Dr. Dan Salamango presented posters.

April
New Publication: Dr. Terumasa Ikeda publishes new report showing capacity of opossum APOBEC1 to restrict retroviruses and retrotransposons in Science Reports titled, "Opossum APOBEC1 is a DNA mutator with retrovirus and retroelement restriction activity."

March
Congratulations to Dr. Reuben Harris for being named a Distinguished McKnight University Professor for the University of Minnesota! The Distinguished McKnight Professorship program recognizes outstanding faculty members who have recently achieved full professor status. Recipients hold the title Distinguished McKnight Professor for as long as they remain at the University of Minnesota.

January
New Publication: Graduate student, Chris Richards, publishes new paper on HIV-1 Vif-derived peptides in JMB titled, "Reassessing APOBEC3G Inhibition by HIV-1 Vif-Derived Peptides."

New Publication: Graduate student, Gabriel Starrett, publishes new paper on mutation signatures in Merkel cell carcinoma in mBio titled, "Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma."

2016      (Click to expand/collapse year)

December
New Publication: Harris and Aihara groups publish the first structures of APOBEC3A-ssDNA and APOBEC3B-ssDNA in NSMB.

Gabriel Starrett wins the 2017 UMN MICaB Outstanding Graduate Student Award. Congratulations Gabe!

November
Dr. Reuben Harris recognized by UMN AHC Academies for Excellence. Congratulations!

October
New Publication: Emily Law and colleagues demonstrate the role of APOBEC3B in cancer drug resistance in the article "The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer" published in Science Advances.

September
New Publication: A new paper by PhD. student Gabriel Starrett titled, "The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis," published in Nature Communications reveals a novel source of mutation in cancer. Links for press release: UMN News, Nature Communications

Welcome to our newest lab member, Dr. Rena Levin-Klein, who has joined the lab and will be working on non-canonical APOBEC activities.

Dr. Reuben Harris gave a keynote presentation at the Conference on Nucleic Acids and Immunity in Brno, Czech Republic.

August
Welcome to our newest lab member, Dr. Teneale Stewart, who has joined the lab and will be working on APOBEC regulation.

The Harris Lab is enjoying the last days of summer by celebrating at our annual lab party. Congratulations to Emily Law for winning the bowling tournament!

July
New Publication: Ph.D. student Gabriel Starrett along with our collaborators Brandy Verhalen and Mengxi Jiang at the University of Alabama-Birmingham recently published the article "Functional upregulation of the DNA cytosine deaminase APOBEC3B by polyomaviruses," in the Journal of Virology.

Congratulations to Team A (Brett Anderson, Adam Cheng, Chris Richards, Brett Anderson, Dan Salamango, and Gabe Starret) for coming in second place at the First Annual Scientific Olympics!

June
New Publication: Dr. Nadine Shaban and our collaborators in the Aihara Lab published a paper titled, "1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure," in the Journal of Molecular Biology.

Dr. Nadine Shaban and Ph.D. student Brett Anderson presented original research at the 2016 NIH Structural Biology Related to HIV/AIDS Meeting in Bethesda, MD.

May
Congratulation to Dr. Daniel Salamango, who was awarded a 3-year postdoctoral fellowship from the Minnesota Craniofacial Research Training (MinnCResT) Program for his proposal on the role of APOBEC3B in HPV-induced cancers.

New Publication: The Harris lab and collaborators published the article, "Mutation processes in 293-based clones overexpressing the DNA cytosine deaminase APOBEC3B," in PLOS One.

Dr. Terumasa Ikeda gave a talk titled, "RT mutations fortify an Env-dependent mechanism that Vif-null HIV-1 can use to escape restriction by APOBEC3G," at the Cold Spring Harbor Laboratory Meeting on Retroviruses. Other lab members, Brett Anderson, Adam Cheng, Diako Ebrahimi, and Chris Richards also presented posters.

March
New Publication: Former and current Ph.D. students Brandon Leonard and Gabriel Starrett co-authored an article entitled, "APOBEC3G expression correlates with T cell infiltration and improved clinical outcomes in high-grade serous ovarian carcinoma," published in Clinical Cancer Research.

February
Congratulations to Jiayi Wang, who received the Interdisciplinary Doctoral Fellowship from the Graduate School for her proposal titled, "Delineating a Novel Barrier to HIV Transmission."

Graduate students, Brett Anderson and Jiayi Wang, presented posters at the 2016 Conference on Opportunistic Infections in Boston, MA.

January
Dr. Reuben Harris lectured at the University of Saskatchewan, Canada.  (Link)

2015      (Click to expand/collapse year)

December 10, 2015
Dr. Reuben Harris talks to ecancertv at SABCS 2015 about his research on APOBEC3B and its correlation to drug resistance in breast cancer. His full presentation at SABCS can be seen here. (Video 1, Video 2, News Brief)

December 8, 2015
Congratulations to Jenny McCann for winning the AACR Susan G. Komen Scholar-in-Training Award at the San Antonio Breast Cancer Symposium. Jenny McCann and Emily Law presented posters at this meeting and Dr. Harris gave a talk.

December 1, 2015
Ph.D. student and Harris Lab member, Chris Richards, had a paper entitled "The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches" published in Science Direct.

November 30, 2015
The Harris Lab is featured on WCCO-TV. Dr. Reuben Harris discusses our research on ovarian cancer and how MOCA support made this possible.

October 1, 2015
The Harris Lab would like to welcome two new postdoctoral research associates to our group, Catherine Waters and Dan Salamango.

September 2015
Ph.D. student and Harris Lab member, Brett Anderson, had a paper entitled Transcriptional regulation of APOBEC3 antiviral immunity through the CBF-β/RUNX axis published in Science Advances.

September 12, 2015
The Harris Lab participated in the MOCA event, HOM Teal Strides for Ovarian Cancer.

September 1, 2015
Dr. Reuben Harris becomes HHMI investigator (HHMI announcement, UMN announcement).

August, 2015
Dr. Michael Carpenter was promoted to Research Assistant Professor.

August 28, 2015
Maggie Olson successfully defended her thesis and will be going onto a postdoctoral research fellowship at the the University of California, San Diego.

August 27, 2015
Brandon Leonard successfully defended his thesis and will be going onto a postdoctoral research fellowship at the University of California, San Francisco.

August, 2015
Adam Cheng was awarded an NIH F30 fellowship.

August 1, 2015
Jennifer McCann began her tenure as an NSF Graduate Research Fellow.

August 1, 2015
Former postdoc in the, Dr. Allison Land, was hired as an Assistant Professor at Minnesota State University, Mankato.